AMPC,2254434-33-6

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AMPC

CAS No. : 2254434-33-6

MCE 国际站：AMPC

产品活性：AMPC 是一种有效的 TFF3 抑制剂。在 TFF3 阳性的 CMS4 结直肠癌细胞中，AMPC 可抑制细胞增殖、存活、致瘤性和 CSC 样行为。AMPC 作为一种潜在的抗癌试剂，可以单独或和 5-FU 联合使用，用于癌症研究。

研究领域：Others

作用靶点：Others

In Vitro: AMPC decreases cell proliferation in CMS4 CRC cells, the IC₅₀ values are 2.63 μM, 4.65 μM, and 69.69 μM, respectively in SW620 (high TFF3 expression), Caco-2, SW480 cells (low TFF3 expression), respectively.
AMPC (1-10 μM) significantly reduces the total cellular levels of TFF3 in SW620 and Caco2 cells in a dose dependent manner.
AMPC induces apoptosis in a dose dependent manner by the inhibition of TFF3, it induces a decrease in the S-phase population and increases caspase3/7 activity compared with control cells.

In Vivo: AMPC (intraperitoneal injection; 40 mg/kg; once daily) leads to a significant reduction of tumour volume in AMPC-treated mice as compared to vehicle-treated mice from day 11 onward. AMPC results in larger areas of tumour necrosis and increased area of cells with apoptotic features in SW620 tumours. AMPC also significantly reduces tumour and serum TFF3 levels in vivo.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Targeted Diversity Library  |  Heterocyclic Compound Library  |  Digitonin  |  5-Ph-IAA  |  FLAG peptide  |  Tocofersolan  |  Monocrotaline  |  Lactate sodium  |  TCEP hydrochloride  |  3X FLAG peptide  |  DPPH  |  Pertussis Toxin  |  Pronase E (Activity ≥ 7000 U/g)  |  O-Propargyl-Puromycin  |  NMDI14  |  Phytohemagglutinin  |  MYLS22  |  Hyaluronidase  |  Biotinyl tyramide  |  Kifunensine  |  Human IgG1 kappa, Isotype Control  |  4-Azido-L-phenylalanine  |  6-Aminonicotinamide  |  Ammonium tetrathiomolybdate(VI)  |  OVA Peptide(257-264) TFA  |  Alkyne-phenol  |  Lauryl maltose neopentyl glycol  |  SHIN1  |  CHAPS  |  Cytosporone B

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds