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- 2025年12月05日
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Antitumor photosensitizer-4
MCE 国际站：Antitumor photosensitizer-4
产品活性：Antitumor photosensitizer-4 (compound 10b) 是一种有效的靶向 ABCG2 的酪氨酸激酶抑制剂 (TKI)。Antitumor photosensitizer-4 是一种光敏剂 (PS)，由达沙替尼 (HY-10181) 和伊马替尼 (HY-15463) 的偶联物组成。Antitumor photosensitizer-4 诱导细胞凋亡 (apoptosis) 和 ROS 产生，对 HepG2 和 B16-F10 细胞表现出强光毒性。
研究领域：Membrane Transporter/Ion Channel | Apoptosis
In Vitro: Antitumor photosensitizer-4 arrests cell cycle at S phase,
In Vivo: Antitumor photosensitizer-4 () inhibits tumor growth and prolong survival time on BALB/c nude mice bearing HepG2 xenograft tumor.
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文献和实验Radiation-Activated Antitumor Vectors
Radiotherapy (RT) is a primary treatment modality for the majority of solid tumors. The objective is to destroy the tumor mass by exposure to ionizing radiation (IR) from an external beam or isotopic source. IR causes DNA damage directly
Gene Therapy for Antitumor Vaccination
for gene delivery and antitumor vaccination within the tumor microenvironment.
Assay for Antitumor and Lectin Activity in RNase Homologs
Lectins, proteins that specifically bind carbohydrates, are widely distributed in animal and plant species. Functions of animal lectins include uptake of serum asialo-glycoproteins into liver, self-defense mechanisms, and modulation of cell
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