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- 保存条件:
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- 规格:
5 mg/10 mg/25 mg/50 mg
| 规格: | 5 mg | 产品价格: | ¥808.0 |
|---|---|---|---|
| 规格: | 10 mg | 产品价格: | ¥1275.0 |
| 规格: | 25 mg | 产品价格: | ¥2550.0 |
| 规格: | 50 mg | 产品价格: | ¥4080.0 |
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Multi-target kinase inhibitor 2
MCE 国际站:Multi-target kinase inhibitor 2
产品活性:Multi-target kinase inhibitor 2 (compound 5K) 是一种 multi-targeted kinase 抑制剂,具有抑制 EGFR、Her2、VEGFR2 和 CDK2 酶的活性,其 IC50 值范围为 40 ~ 204 nM。Multi-target kinase inhibitor 2 对 HepG2、HeLa、MDA-MB-231 和 MCF-7 均有细胞毒作用,IC50 值分别为 41、57、51 和 59 μM。Multi-target kinase inhibitor 2 诱导 HepG2 细胞周期阻滞和凋亡 (apoptosis)。
研究领域:JAK/STAT Signaling | Cell Cycle/DNA Damage | Protein Tyrosine Kinase/RTK
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Quantitative chemoproteomics has recently emerged as an experimental approach to determine protein interaction profiles of small molecules in a given cell line or tissue. In contrast to standard biochemical and biophysical kinase assays
Kinase Inhibitor Selectivity Profiling Using Differential Scanning Fluorimetry
and widely used approach is the direct measurement of the effect of the added ligands on its activity. A variety of enzymatic assay formats have been successfully applied for inhibitor screening of protein kinases. However, enzymatic assays require an active
Mammalian Target of Rapamycin: A Signaling Kinase for Every Aspect of Cellular Life
The mammalian (or mechanistic) target of rapamycin (mTOR) is an evolutionarily conserved serine-threonine kinase that is known to sense the environmental and cellular nutrition and energy status. Diverse mitogens, growth factors
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