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CAS No. : 1054312-81-0
MCE 国际站:FK-3000
产品活性:FK-3000 是一种有效的抗肿瘤剂,可通过细胞凋亡和诱导细胞周期停滞来抑制癌细胞的生长。FK-3000 还表现出针对 HSV-1 和 HIV-1 的抗病毒作用。
研究领域:Apoptosis | Anti-infection
作用靶点:Apoptosis | HSV | HIV
In Vitro: FK-3000 (0-5 μg/mL; 48 h) inhibits cell proliferation, with IC50s of 0.52, 0.77, 0.22, 2.70, 0.40, and 1.90 μg/mL for MDA-MB-231, MCF-7, PC-3, A-431, HT-29, and CT-26 cells, respectively.
FK-3000 (0.5-5.0 μg/mL; 24-48 h) induces MDA-MB-231 cell apoptosis in a dose- and time-dependent manner.
FK-3000 (0.5-5.0 μg/mL; 24-48 h) induces G2/M phase arrest in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner.
FK-3000 (0.5-5.0 μg/mL; 60-120 min or 24-48 h) reduces NF-κB phosphorylation levels and COX-2 expression in MDA-MB-231 cells.
FK-3000 (5.0 μg/mL; 120 min) effectively blocks NF-κB translocation from cytoplasm to nucleus in MDA-MB-231 cells.
In Vivo: FK-3000 (1 mg/kg/day; i.p. daily for 24 d) inhibits tumor growth and shows no signs of toxicity in an MDA-MB-231 xenografted mouse model.
FK-3000 (10-25 mg/kg; p.o. for 10 d) significantly delays skin lesion, limits the development of further lesions and prolongs the mean survival time of HSV-1 infected mice.
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