硫酸钠葡聚糖(DSS),肠炎造模级,分子量36, 000-50,000
Dextran Sulfate Sodium Salt (36,000-50,000 M.Wt.) Colitis GradeKey features and details
1 x 10 g SKU:0216011010
1 x 50 g SKU:0216011050
1 x 100 g SKU:0216011080
1 x 500 g SKU:0216011090
Brand:MP
Key features and details
诱发严重的结肠炎(炎性肠病)
高硫含量:~19%
高手性:+104°比旋光度
低pH:~6.2(1%水溶液
SYNONYMS
DSS, Dextran Sodium Sulfate
CAS NUMBER:
9011-18-1
MOLECULAR WEIGHT:
36,000 - 50,000 Da
MDL NUMBER:
MFCD00081551
PACKAGING OPTIONS
1 x 10 g
1 x 50 g
1 x 100 g
1 x 500 g
Product Description
葡聚糖硫酸钠(Dextran Sulfate Sodium Salt, DSS)是一种多聚阴离子葡聚糖衍生物。DSS通过与结肠
中脂肪酸结合并诱发肠道炎症,从而引发模型动物的结肠炎。
Application Notes
葡聚糖硫酸钠(DSS)是用于诱发模型动物溃疡性结肠炎最常见和最有效的化学诱导剂之一。DSS结肠炎模型
也被广泛应用于结肠炎相关性结肠癌的研究,如长期溃疡性结肠炎患者发生结肠癌的情况。
MP Biomedicals提供肠炎造模领域的金标准—结肠炎造模级葡聚糖硫酸钠(DSS)(分子量36,000-50,000)
和结肠致癌物氧化偶氮甲烷(AOM)。 MP Biomedicals提供的高纯度DSS致炎效果好,是目前结肠炎造
模领域中,文献引用量最高的DSS产品之一,有超过10,000篇文献引用了MP Biomedicals的DSS并成功建立
了相关动物模型。
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use
only, not for direct human use. For more information, please contact our customer service
department.
Key Applications
诱导急性/慢性溃疡性结肠炎模型;诱导慢性结肠炎相关的结肠癌模型
Specifications
SKU 02160110-CF
Alternate Names DSS, Dextran Sodium Sulfate
Application Notes 葡聚糖硫酸钠(DSS)是用于诱发模型动物溃疡性结肠炎最常见和最有效的化学诱导
剂之一。DSS结肠炎模型也被广泛应用于结肠炎相关性结肠癌的研究,如长期溃疡性结肠炎患者发生结肠
癌的情况。MP Biomedicals提供肠炎造模领域的金标准—结肠炎造模级葡聚糖硫酸钠(DSS)
(分子量36,000-50,000)和结肠致癌物氧化偶氮甲烷(AOM)。 MP Biomedicals提供的高纯度DSS致炎
效果好,是目前结肠炎造模领域中,文献引用量最高的DSS产品之一,有超过10,000篇文献引用了MP
Biomedicals的DSS并成功建立了相关动物模型。
Base Catalog Number 160110
Boiling Point 310 ° C
CAS # 9011-18-1
Grade Colitis Grade
Melting Point 92 ° C
Molecular Weight 36,000 - 50,000 Da
Personal Protective Equipment Eyeshields, Gloves, respirator filter
pH (1% aqueous solution) 5-7.11
References
Kinchen, J. Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.
Cell. 2018, 175, 372-386.
Mahalhal , A. Oral iron exacerbates colitis and influences the intestinal microbiome, PLOS ONE. 2018,
13, e0202460.
Dokoshi, T. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight.
2018, 3, e12307.
Zhu, H. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
J. Exp. Clin. Cancer Res. 2017, 36, 2.
Monticelli, L. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on
amphiregulin–EGFR interactions. PNAS. 2015, 112, 10762-10767.
RTECS Number HH9290000
Solubility 100 mg/mL (decreases with increasing of MW)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further
manufacturing use only, not for direct human use. For more information, please contact our customer
service department.
Vapor Pressure 2.6 x 10-4 mm Hg at 25 ° C (Estimated)