GABA A Receptor alpha 1 抗体-GAB

GABA A Receptor alpha 1 抗体，GABA A Receptor alpha 1 Antibody，GABA A Receptor alpha 1 抗体,GABA A Receptor alpha 1 Antibody

产品名称：GABA A Receptor alpha 1 抗体-GABA A Receptor alpha 1 Antibody

产品货号：PSI-XPS-2004-0.1mL

产品规格：0.1mL

背景资料：Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.

保存建议：GABA A Receptor alpha 1 抗体-GABA A Receptor alpha 1 Antibody taken without freeze/thawing due to the presence of 50% glycerol

应用类型：WB

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