Tryptophan (phospho Ser58) Hyd

Tryptophan (phospho Ser58) Hydroxylase 抗体，Tryptophan (phospho Ser58) Hydroxylase Antibody，Tryptophan (phospho Ser58) Hydroxylase 抗体,Tryptophan (phospho Ser58) Hydroxylase Antibody

产品名称：Tryptophan (phospho Ser58) Hydroxylase 抗体-Tryptophan (phospho Ser58) Hydroxylase Antibody

产品货号：PSI-XPS-1030-0.1mL

产品规格：0.1mL

背景资料：Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAM K II). Both PKA and CAM K II phosphorylate Ser58 which lies within the regulatory domain of TPH.

保存建议：Tryptophan (phospho Ser58) Hydroxylase 抗体-Tryptophan (phospho Ser58) Hydroxylase Antibody taken without freeze/thawing due to the presence of 50% glycerol

应用类型：WB

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