IFN-gamma 抗体 (biotin)-IFN-gamm

IFN-gamma 抗体 (biotin)，IFN-gamma Antibody (biotin)，IFN-gamma 抗体 (biotin),IFN-gamma Antibody (biotin)

产品名称：IFN-gamma 抗体 (biotin)-IFN-gamma Antibody (biotin)

产品货号：PSI-XP-5155Bt-0.05mg

产品规格：0.05mg

背景资料：IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains

保存建议：IFN-gamma 抗体 (biotin)-IFN-gamma Antibody (biotin)IFN-gamma antibody is stable for at least 2 years from date of receipt at -20℃

应用类型：E, WB

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