LIGHT 抗体 [7B9H9]-LIGHT Antibod

LIGHT 抗体 [7B9H9]，LIGHT Antibody [7B9H9]，LIGHT 抗体 [7B9H9],LIGHT Antibody [7B9H9]

产品名称：LIGHT 抗体 [7B9H9]-LIGHT Antibody [7B9H9]

产品货号：PSI-RF16062-0.02mg

产品规格：0.02mg

背景资料：LIGHT Antibody: LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation (1) and has recently been identified as an immune checkpoint protein. LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTβR). While LIGHT binding to HVEM delivers a co-stimulatory signal to T cells (1), LIGHT binding to LTβR is critical for the formation of lymphoid structures which can stimulate T cell infiltration and activation of a tumor microenvironment, leading to rapid T cell-mediated tissue destruction (2). It has been shown that targeted delivery of LIGHT to tumors, thereby causing the T cell infiltration of the tumor, can enhance the response of the PD-1/PD-L1 checkpoint blockade anti-cancer therapy (3), suggesting that LIGHT may become a potent tool in anti-cancer treatment.

保存建议：LIGHT 抗体 [7B9H9]-LIGHT Antibody [7B9H9] stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB, IHC-P, ICC, IF, Flow

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