PDL1 抗体 [8E12] (biotin)-PDL1 A

PDL1 抗体 [8E12] (biotin)，PDL1 Antibody [8E12] (biotin)，PDL1 抗体 [8E12] (biotin),PDL1 Antibody [8E12] (biotin)

产品名称：PDL1 抗体 [8E12] (biotin)-PDL1 Antibody [8E12] (biotin)

产品货号：PSI-RF16032-biotin-0.02mg

产品规格：0.02mg

背景资料：PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).

保存建议：PDL1 抗体 [8E12] (biotin)-PDL1 Antibody [8E12] (biotin) stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E

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