ORAI3 抗体 [2H2G9] -ORAI3 Antibo

ORAI3 抗体 [2H2G9] ，ORAI3 Antibody [2H2G9] ，ORAI3 抗体 [2H2G9] ,ORAI3 Antibody [2H2G9]

产品名称：ORAI3 抗体 [2H2G9] -ORAI3 Antibody [2H2G9]

产品货号：PSI-PM-4911-0.02mg

产品规格：0.02mg

背景资料：ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.

保存建议：ORAI3 抗体 [2H2G9] -ORAI3 Antibody [2H2G9] stored at -20℃, stable for one year

应用类型：E, WB, IHC-P, IF

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