Apaf-1 抗体 [5E11] -Apaf-1 Antib

Apaf-1 抗体 [5E11] ，Apaf-1 Antibody [5E11] ，Apaf-1 抗体 [5E11] ,Apaf-1 Antibody [5E11]

产品名称：Apaf-1 抗体 [5E11] -Apaf-1 Antibody [5E11]

产品货号：PSI-PM-2016-0.02mg

产品规格：0.02mg

背景资料：Apaf-1 Monoclonal Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.

保存建议：Apaf-1 抗体 [5E11] -Apaf-1 Antibody [5E11] stored at -20℃, stable for one year

应用类型：E, IHC-P

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