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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
DBA/2 mouse spleen cells
- 保存条件:
Store vial at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
WB, IHC-Fr, ICC, Flow
- 抗体英文名:
CD72.1 Antibody [10.1.D2]
- 抗体名:
CD72.1 Antibody [10.1.D2]
- 规格:
0.5mg
CD72.1 抗体 [10.1.D2],CD72.1 Antibody [10.1.D2],CD72.1 抗体 [10.1.D2],CD72.1 Antibody [10.1.D2]
产品名称:CD72.1 抗体 [10.1.D2]-CD72.1 Antibody [10.1.D2]
产品货号:PSI-98-840-0.5mg
产品规格:0.5mg
背景资料:Murine CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and a small number of B cells. The 10.1.D2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. However, 10.1.D2 can itself trigger a positive signal by binding CD72.
保存建议:CD72.1 抗体 [10.1.D2]-CD72.1 Antibody [10.1.D2]Store vial at 2-8℃
应用类型:WB, IHC-Fr, ICC, Flow
点击:CD72.1 抗体 [10.1.D2]-CD72.1 Antibody [10.1.D2]查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验Nature 综述导读:FDA 批准第 100 个抗体药物!抗体药物的研究方向在哪里?
批准了第 50 种抗体,距离第一个抗体已经过去了 29 年。2021 年 4 月,随着葛兰素史克 PD1 阻断剂 dostarlimab 的批准,抗体药物仅用了 6 年多的时间就达到了 100 个,进入了「百抗」新时代(图五)。 图五 Nature Reviews Drug Discovery 20, 10 (2021) 上面提到的 100 个抗体并不是单纯经典的单克隆的裸抗体(naked antibody),其中也包括了抗体片段已经工程化修饰抗体的各种偶联形式。其中包括有抗体药物偶联(ADC
: 1. Prepare Whole Cell Extract. Make sure every solution DOES NOT contain DTT. 2. Add 1 or 2 μl of non-diluted monoclonal antibody (4B4 is better than 10H8 for HSF1) or 1/10 diluted polyclonal antibody to 10 μg of whole cell extract
and pellet as above. Resuspend in 10 mls of PBS. Put 200 ul (3 mg/ml) of the antibody to an eppendorf tube. Add 0.8 mls of PBS. Pellet 1 ml of the cell suspension and discard the PBS supernatant. Add the antibody solution to the cell pellet
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