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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
P815 cells
- 保存条件:
Store vial at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
大鼠
- 应用范围:
Flow
- 抗体英文名:
CD49d Antibody [PS/2] (PE)
- 抗体名:
CD49d Antibody [PS/2] (PE)
- 规格:
0.1mg
CD49d 抗体 [PS/2] (PE),CD49d Antibody [PS/2] (PE),CD49d 抗体 [PS/2] (PE),CD49d Antibody [PS/2] (PE)
产品名称:CD49d 抗体 [PS/2] (PE)-CD49d Antibody [PS/2] (PE)
产品货号:PSI-98-552-0.1mg
产品规格:0.1mg
背景资料:VLA-4 belongs to the beta1-integrin family, which functions both as cell-matrix and cell-cell receptors. As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/Pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive. Antibody PS/2 also reacts with human VLA-4.
保存建议:CD49d 抗体 [PS/2] (PE)-CD49d Antibody [PS/2] (PE)Store vial at 2-8℃
应用类型:Flow
点击:CD49d 抗体 [PS/2] (PE)-CD49d Antibody [PS/2] (PE)查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验ITGA4(CD49D)信号通路、病理作用与靶向治疗药物研究梳理
整合素alpha 4(ITGA4),又称CD49D,是整合素家族的关键亚基。它通过与β1或β7亚基结合,形成功能性异二聚体α4β1(VLA-4)和α4β7,在免疫细胞的黏附、运输及迁移中扮演核心角色。VLA-4还能介导白细胞在活化内皮细胞上的聚集。鉴于ITGA4在多发性硬化、炎症性肠病等多种自身免疫性疾病的病理过程中发挥关键作用,它已成为治疗干预的重要靶点。 ITGA4的表达分布 ITGA4主要分布于巨核细胞、红细胞、干细胞、NK细胞以及T细胞中。在T细胞亚群中,CD49D主要在CD
Methods for the Detection of D-Amino-Acid Oxidase
kidney D-amino-acid oxidase (Sigma, St. Louis, MO or Boehringer Mannheim, Germany) was used as a control. Organs, tissues, or tissue culture cells were homogenized in distilled water and centrifuged at 550 x g for 5 min. The supernatant solutions
反应发生的风险,故而在合成磷酸化多肽时,需要对氨基酸投料量、反应方法以及反应时长等进行优化调整以期达到更理想、更经济的合成效果。我们有针对性地对磷酸化多肽合成条件进行了探索和调整,采用最终的优化条件成功合成了含有多达六个磷酸化丝氨酸残基的多肽:FAM-Ahx-X(pS)XX(pS)X(pS)X(pS)XX(pS)X(pS)-NH2(客户肽,详细序列未给出;其氨基端标记FAM以进行荧光检测),经过RP-HPLC纯化后最终纯品的纯度高达95%(见Figure 3)。 参考文献: 1. P
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