p53 (Ab 9) 抗体-p53 (Ab 9) Antib

p53 (Ab 9) 抗体，p53 (Ab 9) Antibody，p53 (Ab 9) 抗体,p53 (Ab 9) Antibody

产品名称：p53 (Ab 9) 抗体-p53 (Ab 9) Antibody

产品货号：PSI-79-530-0.1mg

产品规格：0.1mg

背景资料：p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

保存建议：p53 (Ab 9) 抗体-p53 (Ab 9) AntibodyStore antibody at -20℃ for up to one year

应用类型：WB

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