JNK1 / JNK2 (phospho Thr183 /

JNK1 / JNK2 (phospho Thr183 / Tyr185) 抗体，JNK1 / JNK2 (phospho Thr183 / Tyr185) Antibody，JNK1 / JNK2 (phospho Thr183 / Tyr185) 抗体,JNK1 / JNK2 (phospho Thr183 / Tyr185) Antibody

产品名称：JNK1 / JNK2 (phospho Thr183 / Tyr185) 抗体-JNK1 / JNK2 (phospho Thr183 / Tyr185) Antibody

产品货号：PSI-79-504-0.1mg

产品规格：0.1mg

背景资料：Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it./Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

保存建议：JNK1 / JNK2 (phospho Thr183 / Tyr185) 抗体-JNK1 / JNK2 (phospho Thr183 / Tyr185) AntibodyStore antibody at -20℃ for up to one year

应用类型：WB, IF

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