ATG5 抗体 [1358CT289.125.123]-AT

ATG5 抗体 [1358CT289.125.123]，ATG5 Antibody [1358CT289.125.123]，ATG5 抗体 [1358CT289.125.123],ATG5 Antibody [1358CT289.125.123]

产品名称：ATG5 抗体 [1358CT289.125.123]-ATG5 Antibody [1358CT289.125.123]

产品货号：PSI-64-229-100ul

产品规格：100ul

背景资料：Involved in autophagy vesicles formation. Conjugation with ATG12 through an ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12- ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. HCV utilizes ATG5 as a proviral factor during the onset of viral infection. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures; as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.

保存建议：ATG5 抗体 [1358CT289.125.123]-ATG5 Antibody [1358CT289.125.123]Store at 4℃ for three months and -20℃, stable for up to one year

应用类型：WB

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