- ￥22
- ProSci
- 美国
- PSI-57-625-400ul
- 2025年07月13日
- WB
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
This Mouse Rps6kb1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-509 amino acids from the C-terminal region of mouse Rps6kb1.
- 保存条件：
Store at 4℃ for three months and -20℃, stable for up to one year
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
兔
- 应用范围：
WB
- 抗体英文名：
Mouse Rps6kb1 Antibody
- 抗体名：
Mouse Rps6kb1 Antibody
- 规格：
400ul
Mouse Rps6kb1 抗体，Mouse Rps6kb1 Antibody，Mouse Rps6kb1 抗体,Mouse Rps6kb1 Antibody
产品名称：Mouse Rps6kb1 抗体-Mouse Rps6kb1 Antibody
产品货号：PSI-57-625-400ul
产品规格：400ul
背景资料：Rps6kb1 acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling; probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance; probably phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at 'Ser-136' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex; probably phosphorylates RMP at 'Ser-136'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates POLDIP3 (By similarity).
保存建议：Mouse Rps6kb1 抗体-Mouse Rps6kb1 AntibodyStore at 4℃ for three months and -20℃, stable for up to one year
应用类型：WB
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文献和实验Isotype-specific immunostaining with mouse primary antibodies on mouse tissue
) Briefly, substitute your anti H+L pan-reactive secondary antibody with an anti-isotype heavy chain specific secondary. Be aware of possible odd crossreactivties (e.g. many goat anti mouse IgG 1 heavy chain do stain rat IgG 2a
Euthanasia Euthanasia and mouse necropsies require prior IACUC approval. The mode of euthanasia should be chosen which minimizes pain or distress
Immunostaining of Mouse Atherosclerotic Lesions
and regulators in lesions. The principle of the technique is that an antibody is incubated with the tissue under conditions that favor a specific interaction with its antigen. This is subsequently visualized most commonly by a chromogenic substrate that produces
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