Fibrillarin 抗体 [38F3] -Fibrill

Fibrillarin 抗体 [38F3] ，Fibrillarin Antibody [38F3] ，Fibrillarin 抗体 [38F3] ,Fibrillarin Antibody [38F3]

产品名称：Fibrillarin 抗体 [38F3] -Fibrillarin Antibody [38F3]

产品货号：PSI-50-266-0.1mL

产品规格：0.1mL

背景资料：Nop1p was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae. The Nop1p protein is 327 amino acids in size (34.5 kDa), is essential for yeast viability, and is localized in the nucleoli. The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34 kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable. This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species (e.g. 4-6).

保存建议：Fibrillarin 抗体 [38F3] -Fibrillarin Antibody [38F3] stored at -20℃ and is stable at -20℃ for at least 1 year

应用类型：WB, IHC

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