NMDA (phospho Ser1480) 抗体-NMDA

NMDA (phospho Ser1480) 抗体，NMDA (phospho Ser1480) Antibody，NMDA (phospho Ser1480) 抗体,NMDA (phospho Ser1480) Antibody

产品名称：NMDA (phospho Ser1480) 抗体-NMDA (phospho Ser1480) Antibody

产品货号：PSI-50-234-0.1mL

产品规格：0.1mL

背景资料：The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). It has been shown that phosphorylation of Ser1480 disrupts the interaction of NR2B with the PDZ domains of PSD-95 and SAP102 and decreases surface NR2B expression in neurons (Chung et al., 2004).

保存建议：NMDA (phospho Ser1480) 抗体-NMDA (phospho Ser1480) Antibody stored at -20℃ and is stable at -20℃ for at least 1 year

应用类型：WB

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