GABAA Receptor 抗体-GABAA Recept

GABAA Receptor 抗体，GABAA Receptor Antibody，GABAA Receptor 抗体,GABAA Receptor Antibody

产品名称：GABAA Receptor 抗体-GABAA Receptor Antibody

产品货号：PSI-50-210-0.1mL

产品规格：0.1mL

背景资料：Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).

保存建议：GABAA Receptor 抗体-GABAA Receptor Antibody stored at -20℃ and is stable at -20℃ for at least 1 year

应用类型：WB, IHC

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