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- 爱必信(absin)
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- 2025年07月10日
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- 文献和实验
- 技术资料
- 库存：
现货
- 英文名：
Curcumin;Indian Saffron; Turmeric yellow; Natural Yellow 3; Diferuloylmethane
- CAS号：
458-37-7
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 供应商：
爱必信(上海)生物科技有限公司
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 规格：
50mg/200mg
| 规格： | 50mg | 产品价格： | ￥453.0 |
|---|---|---|---|
| 规格： | 200mg | 产品价格： | ￥926.0 |
| 产品描述 | |
| 描述 | Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM） and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 姜黄素；Indian Saffron; Turmeric yellow; Natural Yellow 3; Diferuloylmethane |
| 外观 | 橙色粉末 |
| 可溶性/溶解性 | DMSO : 3.7 mg/mL (10 mM) Ethanol : 1.8 mg/mL (5 mM) |
| 生物活性 | |
| 靶点 | Nrf2 ,HDAC ,NF-κB ,p300 histone acetylatransferase |
| In vitro(体外研究) | Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells. |
| In vivo(体内研究) | Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB. |
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文献和实验- Curcumin protects human umbilical vein endothelial cells against high oxidized low density lipoprotein-induced lipotoxicity and modulates autophagyLifeng Zhao, Ruixi Luo, Honghong Yu, Shuaishuai Li, Qi Yu, Wenjia Wang, Kun Cai, Tao Xu, Rui Chen, Weiyi Tian
Iranian Journal of Basic Medical Sciences. 2021 Nov 10 .
影响因子： 2.66
SC8670 姜黄素 Curcumin HPLC≥98% 20mg SG8040 没食子酸 Gallic acid HPLC≥98
现代医学研究表明，生姜含姜辣素、姜黄素等活性成分，具有抗炎、抗氧化、调节胃肠动力及保护胃黏膜的作用，可辅助改善消化不良、减轻炎症反应。其传统药用价值与现代药理研究相互印证，既是日常调味食材，也在中西医结合调理胃肠疾病、缓解炎症相关不适中发挥作用。被生姜外泌体的功效圈粉后，更关键的是搞懂 “怎么提” 才够好！高纯度 + 高稳定性的核心秘诀，都在我们的提取工艺里，下文详细揭秘～ 推荐提取
1. 接种前可将完全培养基置于培养箱平衡 15 min 以上，使 pH 稳定在 7.0-7.6。 2. 消化时避免摇晃培养瓶，可 37℃ 孵育加速消化。 3. 血清蛋白可竞争性抑制胰酶活性。 4. 传代比例为 1:4-1:8。 5. 冻存密度控制在 1-10×10? cells/mL。 6. DMSO 需最后添加，加完后迅速转移至低温环境梯度冻存。 Caco-2 细胞 人结肠腺癌细胞，贴壁生长，为多边形或梭形，增殖速度较快[15]。 培养条件：DMEM
