PAG/Cbp 抗体-PAG/Cbp Antibody

PAG/Cbp 抗体，PAG/Cbp Antibody，PAG/Cbp 抗体,PAG/Cbp Antibody

产品名称：PAG/Cbp 抗体-PAG/Cbp Antibody

产品货号：PSI-36-345-100ug

产品规格：100ug

背景资料：PAG [Cbp] is a ubiquitously expressed transmembrane adapter protein. Depending on its phosphorylation status, it appears as diffuse band(s) of 80-90kDa by SDS-PAGE, with phosphorylation leading to a shift towards a higher apparent molecular mass. Tyrosine phosphorylated PAG recruits Csk to the membrane and negatively regulates Src family kinases via Csk-mediated phosphorylation. Upon T cell receptor engagement, PAG becomes dephosphorylated, thereby displacing Csk from the membrane and enabling the activation of the Src kinases Fyn and Lck. PAG negatively regulates TCR (T cell antigen receptor)-mediated signaling in T cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. It inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins and may be involved in cell adhesion signaling.

保存建议：PAG/Cbp 抗体-PAG/Cbp AntibodyStable for at least 1 year after receipt when stored at -20℃

应用类型：ICC, IP, WB

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