Caspase-8 抗体 [1G12]-Caspase-8

Caspase-8 抗体 [1G12]，Caspase-8 Antibody [1G12]，Caspase-8 抗体 [1G12],Caspase-8 Antibody [1G12]

产品名称：Caspase-8 抗体 [1G12]-Caspase-8 Antibody [1G12]

产品货号：PSI-36-180-100ug

产品规格：100ug

背景资料：Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.

保存建议：Caspase-8 抗体 [1G12]-Caspase-8 Antibody [1G12]Stable for at least 1 year after receipt when stored at -20℃

应用类型：E, Flow, IHC, WB

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