Caspase-2 抗体 [11B4]-Caspase-2

Caspase-2 抗体 [11B4]，Caspase-2 Antibody [11B4]，Caspase-2 抗体 [11B4],Caspase-2 Antibody [11B4]

产品名称：Caspase-2 抗体 [11B4]-Caspase-2 Antibody [11B4]

产品货号：PSI-36-179-100ug

产品规格：100ug

背景资料：Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.

保存建议：Caspase-2 抗体 [11B4]-Caspase-2 Antibody [11B4]Stable for at least 1 year after receipt when stored at -20℃

应用类型：E, Flow, ICC, IHC, IP, WB

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