Cardif 抗体 [Adri-1]-Cardif Anti

Cardif 抗体 [Adri-1]，Cardif Antibody [Adri-1]，Cardif 抗体 [Adri-1],Cardif Antibody [Adri-1]

产品名称：Cardif 抗体 [Adri-1]-Cardif Antibody [Adri-1]

产品货号：PSI-36-098-100ug

产品规格：100ug

背景资料：RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.

保存建议：Cardif 抗体 [Adri-1]-Cardif Antibody [Adri-1]Stable for at least 1 year after receipt when stored at -20℃

应用类型：ICC, IHC, IP, WB

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