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- ProSci
- 美国
- PSI-36-097-100ug
- 2025年07月12日
- Func, ICC, IP
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
- 保存条件：
Stable for at least 1 year after receipt when stored at -20℃
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
小鼠
- 应用范围：
Func, ICC, IP
- 抗体英文名：
NS5B Antibody [5B-12B7]
- 抗体名：
NS5B Antibody [5B-12B7]
- 规格：
100ug
NS5B 抗体 [5B-12B7]，NS5B Antibody [5B-12B7]，NS5B 抗体 [5B-12B7],NS5B Antibody [5B-12B7]
产品名称：NS5B 抗体 [5B-12B7]-NS5B Antibody [5B-12B7]
产品货号：PSI-36-097-100ug
产品规格：100ug
背景资料：The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
保存建议：NS5B 抗体 [5B-12B7]-NS5B Antibody [5B-12B7]Stable for at least 1 year after receipt when stored at -20℃
应用类型：Func, ICC, IP
点击：NS5B 抗体 [5B-12B7]-NS5B Antibody [5B-12B7]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
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文献和实验Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)
studies of several recombinant HCV nonstructural proteins have been initiated, our knowledge of the HCV NS5B polymerase that encodes an RNA-dependent RNA polymerase (RDRP) is rudimentary (4 –8 ). RNA-dependent RNA polymerases represent a class of viral
Preparation and Handling of Hepatitis C Viral Proteins NS3 and NS5B for Structural Studies
protease and the NS5B RNA-dependent RNA polymerase are the most popular targets from a drug-discovery perspective. A number of active-site inhibitors of the NS3 protease as well as allosteric inhibitors of the NS5B polymerase are being developed
to measure the interaction between hepatitis C virus NS5B polymerase (wild type and/or mutants) and a small-molecule inhibitor. Viral polymerase proteins are captured on a Ni2+ -nitrilotriacetic acid sensor surface while the small-�molecule inhibitors
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