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- 文献和实验
- 技术资料
- 免疫原:
The microsomal fraction of human renal cortical tissue homogenate was used as the immunogen for this CA9 antibody.
- 保存条件:
Aliquot and Store at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
Flow, IF, WB, IHC
- 抗体英文名:
CA9 Antibody [SPM314]
- 抗体名:
CA9 Antibody [SPM314]
- 规格:
100ug
CA9 抗体 [SPM314],CA9 Antibody [SPM314],CA9 抗体 [SPM314],CA9 Antibody [SPM314]
产品名称:CA9 抗体 [SPM314]-CA9 Antibody [SPM314]
产品货号:PSI-34-184-100ug
产品规格:100ug
背景资料:Recognizes a glycoprotein of ~200kDa, identified as carbonic anhydrase IX (CAIX/CA9/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, CA9 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, CA9 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This mAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
保存建议:CA9 抗体 [SPM314]-CA9 Antibody [SPM314]Aliquot and Store at 2-8℃
应用类型:Flow, IF, WB, IHC
点击:CA9 抗体 [SPM314]-CA9 Antibody [SPM314]查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
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,随后研究发现,其在多种肿瘤组织中出现异常表达,包括尿路上皮癌、乳腺癌、肺癌以及胰腺癌等 [10]。 相比正常成人组织,部分肿瘤细胞中Nectin-4表达明显升高,同时其位于细胞表面的特点使其具有较好的抗体可及性。这些特征使Nectin-4成为抗体药物开发的重要候选靶点。 目前最具代表性的应用是靶向Nectin-4的抗体偶联药物(antibody-drug conjugate, ADC)——Enfortumab vedotin。该药物利用抗Nectin-4抗体识别肿瘤细胞表面的Nectin
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