Complement 4d 抗体 [SPM545]-Comp

Complement 4d 抗体 [SPM545]，Complement 4d Antibody [SPM545]，Complement 4d 抗体 [SPM545],Complement 4d Antibody [SPM545]

产品名称：Complement 4d 抗体 [SPM545]-Complement 4d Antibody [SPM545]

产品货号：PSI-34-175-100ug

产品规格：100ug

背景资料：This mAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d. C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.

保存建议：Complement 4d 抗体 [SPM545]-Complement 4d Antibody [SPM545]Aliquot and Store at 2-8℃

应用类型：E, IF, IHC

点击：Complement 4d 抗体 [SPM545]-Complement 4d Antibody [SPM545]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。