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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Extract of pigmented melanoma metastases from lymph nodes was used as the immunogen for this gp100 antibody.
- 保存条件:
Aliquot and Store at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
Flow, IF, IHC
- 抗体英文名:
gp100 Antibody [SPM142]
- 抗体名:
gp100 Antibody [SPM142]
- 规格:
100ug
gp100 抗体 [SPM142],gp100 Antibody [SPM142],gp100 抗体 [SPM142],gp100 Antibody [SPM142]
产品名称:gp100 抗体 [SPM142]-gp100 Antibody [SPM142]
产品货号:PSI-34-163-100ug
产品规格:100ug
背景资料:By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This mAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. It stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma.
保存建议:gp100 抗体 [SPM142]-gp100 Antibody [SPM142]Aliquot and Store at 2-8℃
应用类型:Flow, IF, IHC
点击:gp100 抗体 [SPM142]-gp100 Antibody [SPM142]查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验Nature 综述导读:FDA 批准第 100 个抗体药物!抗体药物的研究方向在哪里?
批准了第 50 种抗体,距离第一个抗体已经过去了 29 年。2021 年 4 月,随着葛兰素史克 PD1 阻断剂 dostarlimab 的批准,抗体药物仅用了 6 年多的时间就达到了 100 个,进入了「百抗」新时代(图五)。 图五 Nature Reviews Drug Discovery 20, 10 (2021) 上面提到的 100 个抗体并不是单纯经典的单克隆的裸抗体(naked antibody),其中也包括了抗体片段已经工程化修饰抗体的各种偶联形式。其中包括有抗体药物偶联(ADC
相关专题单克隆抗体 单克隆抗体问世以来,在临床诊断、治疗与预防等方面发挥了巨大的作用。但是常用的鼠源单克隆抗 体具有较强的免疫原性,在临床反复应用中会引起人抗鼠抗体(human anti -mouse antibody,HAMA)反应, 导致半衰期缩短,治疗效果减弱。鼠源抗体人源化是指利用DNA 重组技术和蛋白质工程技术,对抗体基 因进行重组,在保留鼠源抗体对抗原有效结合部位的同时,最大限度地降低非结合部位的鼠源性。这种通 过重组基因所表达
E.Z.N.A. Mag-Bind Blood DNA Protocol (1-100 ul Blood)
实验试剂 Regents to be provided by user 1. Absolute ethanol (96%-100%) 实验设备 Equipments to be provided by user 1. Nuclease-free 1.5 mL centrifuge tube (for single tube preparation)
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