p53 抗体 [PAb 122]-p53 Antibody

p53 抗体 [PAb 122]，p53 Antibody [PAb 122]，p53 抗体 [PAb 122],p53 Antibody [PAb 122]

产品名称：p53 抗体 [PAb 122]-p53 Antibody [PAb 122]

产品货号：PSI-33-854-100ug

产品规格：100ug

背景资料：This antibody is specific to a conserved determinant of the p53 protein. PAb 122 binds to the C-terminus (aa 370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb 122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). The protein in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Its the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.

保存建议：p53 抗体 [PAb 122]-p53 Antibody [PAb 122]Aliquot and Store at 2-8℃

应用类型：WB, Flow, IHC-Fr, IF

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