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- ProSci
- 美国
- PSI-33-699-100ug
- 2025年07月12日
- WB, Flow, IHC, IF
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.
- 保存条件：
Aliquot and Store at 2-8℃
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
小鼠
- 应用范围：
WB, Flow, IHC, IF
- 抗体英文名：
FOXA1 Antibody [FOXA1/1515]
- 抗体名：
FOXA1 Antibody [FOXA1/1515]
- 规格：
100ug
FOXA1 抗体 [FOXA1/1515]，FOXA1 Antibody [FOXA1/1515]，FOXA1 抗体 [FOXA1/1515],FOXA1 Antibody [FOXA1/1515]
产品名称：FOXA1 抗体 [FOXA1/1515]-FOXA1 Antibody [FOXA1/1515]
产品货号：PSI-33-699-100ug
产品规格：100ug
背景资料：The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.
保存建议：FOXA1 抗体 [FOXA1/1515]-FOXA1 Antibody [FOXA1/1515]Aliquot and Store at 2-8℃
应用类型：WB, Flow, IHC, IF
点击：FOXA1 抗体 [FOXA1/1515]-FOXA1 Antibody [FOXA1/1515]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
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文献和实验Using MACS to Identify Peaks from ChIP‐Seq Data
Lupien, M., Eeckhoute, J., Meyer, C.A., Wang, Q., Zhang, Y., Li, W., Carroll, J.S., Liu, X.S., and Brown, M. 2008. FoxA1 translates epigenetic signatures into enhancer driven lineage‐specific transcription. Cell 132:958‐970
A Detailed Protocol for Formaldehyde‐Assisted Isolation of Regulatory Elements (FAIRE)
Eeckhoute, J., Lupien, M., Meyer, C., Verzi, M., Shivdasani, R., Liu, X.S., and Brown, M. 2009. Cell‐type selective chromatin remodeling defines the active subset of FOXA1‐bound enhancers. Genome Res. 19:372‐380
效率，还可以使传统方法难于复性的蛋白质成功折叠。胃蛋白酶难于在体外复性，甚至以为不可能在体外复性，但是Kurimoto 等人[38]发现吸附在琼脂糖上的胃蛋白酶可以在pH3－5 的条件下复性，并且复性时间特别长，最后他们在pH5 的条件下获得了60% 的复性效率。这是第一次体外成功复性胃蛋白酶的报道。 吸附辅助复性 与蛋白质直接可逆的吸附在层析介质上，以降低聚集体形成的机制不同，一些有助于蛋白质折叠的小分子，如分子伴侣、抗体，可以共价结合在层析介质上，然后使蛋白质进入到层析柱中复性
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