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- ￥22
- ProSci
- 美国
- PSI-33-664-100ug
- 2025年07月15日
- Flow, IF, E
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human protein used as the immunogen for the CD80 antibody.
- 保存条件：
Aliquot and Store at 2-8℃
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
小鼠
- 应用范围：
Flow, IF, E
- 抗体英文名：
CD80 Antibody [C80/1608]
- 抗体名：
CD80 Antibody [C80/1608]
- 规格：
100ug
CD80 抗体 [C80/1608]，CD80 Antibody [C80/1608]，CD80 抗体 [C80/1608],CD80 Antibody [C80/1608]
产品名称：CD80 抗体 [C80/1608]-CD80 Antibody [C80/1608]
产品货号：PSI-33-664-100ug
产品规格：100ug
背景资料：T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
保存建议：CD80 抗体 [C80/1608]-CD80 Antibody [C80/1608]Aliquot and Store at 2-8℃
应用类型：Flow, IF, E
点击：CD80 抗体 [C80/1608]-CD80 Antibody [C80/1608]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
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文献和实验,2F12;CRIS-3 Leu LFA-1(gp180/95)的α链 与ICAM-1（CD54）和ICAM-2（CD102）结合 CD11b Mol,OKM1; (Mac-1,CR3,integrin αm G,M,NK gp165/95的α链 C3bi和FB受体，与ICAM-1结合，粘附，调理吞噬 CD11c LeuM5;(CR4,integrin αx) M,G,NK,Tsub gp150/95的α链 C3bi受体，调理吞噬
连蛋白结合后抑制Syk信号通路，削弱其对肿瘤细胞的杀伤能力。在髓系细胞中，LILRB4通过招募SHP-1抑制巨噬细胞活化，降低TNF-α释放和吞噬功能；与Galectin-8结合后激活STAT3、抑制NF-κB，促进M-MDSC向免疫抑制表型极化，分泌ARG1和IL-10，进一步抑制T细胞功能，共同构建免疫抑制微环境。 LILRB4通过调控免疫耐受微环境促进免疫抑制。其在树突状细胞上高表达，诱导耐受性表型，减少CD80/CD86表达并促进Treg分化。作为抗原捕获受体，参与APCs信号整合，调节适应性免疫
28 9.3 Tsub,Ba gp44 与CD80、CD86互为配体 续表2 CD 常用克隆抗体或代号（ ） 主要表达细胞 分子量（kDa)和结构 功能 CD29 4B
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