CD16 抗体 [HO-80]-CD16 Antibody

CD16 抗体 [HO-80]，CD16 Antibody [HO-80]，CD16 抗体 [HO-80],CD16 Antibody [HO-80]

产品名称：CD16 抗体 [HO-80]-CD16 Antibody [HO-80]

产品货号：PSI-33-358-100ug

产品规格：100ug

背景资料：It recognizes CD16 (Fcgamma;RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16, CD16A (Fcgamma;RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fcgamma;RIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

保存建议：CD16 抗体 [HO-80]-CD16 Antibody [HO-80]Aliquot and Store at 2-8℃

应用类型：Func, Flow, IF

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