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- 文献和实验
- 技术资料
- 免疫原:
Stimulated human leukocytes were used as the immunogen for the CD3e antibody.
- 保存条件:
Aliquot and Store at 2-8℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
小鼠
- 应用范围:
Func, Flow, IF
- 抗体英文名:
CD3e Antibody [CRIS-7]
- 抗体名:
CD3e Antibody [CRIS-7]
- 规格:
100ug
CD3e 抗体 [CRIS-7],CD3e Antibody [CRIS-7],CD3e 抗体 [CRIS-7],CD3e Antibody [CRIS-7]
产品名称:CD3e 抗体 [CRIS-7]-CD3e Antibody [CRIS-7]
产品货号:PSI-33-484-100ug
产品规格:100ug
背景资料:Recognizes the epsilon-chain of CD3 (Workshop V; Code: CD03.09), which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.
保存建议:CD3e 抗体 [CRIS-7]-CD3e Antibody [CRIS-7]Aliquot and Store at 2-8℃
应用类型:Func, Flow, IF
点击:CD3e 抗体 [CRIS-7]-CD3e Antibody [CRIS-7]查看更详细产品说明,更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论,请点击查看艾美捷特色产品中心。
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文献和实验细胞的抗原表达模式也存在差异,研究中需结合组织特异性合理搭配抗体。 Mouse CD3,CD3e和CD3复合体 CD3与CD3e是流式细胞术中检测小鼠总T细胞群的首xuan标志物,适用于绝大多数实验品系。它们广泛表达于所有T细胞亚群表面(涵盖αβTCR和γδTCR),能够实现对T细胞的全面鉴定。需要特别注意的是,在某些基因修饰小鼠模型中(例如TCR敲除模型),由于基因层面的改变,CD3ε链的表达可能会受到限制或出现异常。在这种情况下,单独使用针对CD3e的抗体可能导致T细胞漏检。因此,建议改用识别
Simultaneous Detection of Multiple Cytokines in ELISPOT Assays
-backed Millipore 96-well plates. Several cell stimulations were also used, including Concanavalin A, Phorbol Myristate Acetate (PMA) and calcium ionophore (Cal), phytohemagglutinin, CD3e, and lipopolysaccharide. Biotinylated antibodies were used
补充精氨酸能抗癌?Nature:用细菌把「肿瘤克星」送到抗癌前线,免疫治疗效果提高 30%
菌株,单独或合并抗 PD-L1 抗体。结果发现,合并用药降低了肿瘤的生长速率,并且 74% 使用了合并疗法的小鼠甚至根除了肿瘤。与之相对的,单独使用抗 PD-L1 抗体或与野生型菌株合并使用,分别只有 44% 和 39% 的小鼠根除了肿瘤。这增加的 30% 根除肿瘤的治疗效果可归功于生物工程编辑的细菌。综合这些结果可知,L-Arg 菌株增强了 PD-L1 介导的免疫治疗。接下来,研究者试图探究是否该免疫治疗效果是由 T 细胞介导的。他们在 T 细胞缺陷的 cd3e-/-小鼠中重复了上述实验,同样
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