p57Kip2 抗体 [57P06]-p57Kip2 Ant

p57Kip2 抗体 [57P06]，p57Kip2 Antibody [57P06]，p57Kip2 抗体 [57P06],p57Kip2 Antibody [57P06]

产品名称：p57Kip2 抗体 [57P06]-p57Kip2 Antibody [57P06]

产品货号：PSI-33-320-100ug

产品规格：100ug

背景资料：Recognizes a protein of 57kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.

保存建议：p57Kip2 抗体 [57P06]-p57Kip2 Antibody [57P06]Aliquot and Store at 2-8℃

应用类型：WB, Flow, IF, IHC-P

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