Thymidylate Synthase 抗体 [TMS71

Thymidylate Synthase 抗体 [TMS715]，Thymidylate Synthase Antibody [TMS715]，Thymidylate Synthase 抗体 [TMS715],Thymidylate Synthase Antibody [TMS715]

产品名称：Thymidylate Synthase 抗体 [TMS715]-Thymidylate Synthase Antibody [TMS715]

产品货号：PSI-33-219-100ug

产品规格：100ug

背景资料：This antibody is specific for a protein of 36kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

保存建议：Thymidylate Synthase 抗体 [TMS715]-Thymidylate Synthase Antibody [TMS715]Aliquot and Store at 2-8℃

应用类型：Flow, IHC, IF

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