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- ProSci
- 美国
- PSI-33-139-100ug
- 2025年07月12日
- Flow, IF
- 小鼠
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human HIF1 alpha was used as the immunogen for this antibody.
- 保存条件：
Aliquot and Store at 2-8℃
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
小鼠
- 应用范围：
Flow, IF
- 抗体英文名：
HIF1 alpha Antibody [HIF1A-84]
- 抗体名：
HIF1 alpha Antibody [HIF1A-84]
- 规格：
100ug
HIF1 alpha 抗体 [HIF1A-84]，HIF1 alpha Antibody [HIF1A-84]，HIF1 alpha 抗体 [HIF1A-84],HIF1 alpha Antibody [HIF1A-84]
产品名称：HIF1 alpha 抗体 [HIF1A-84]-HIF1 alpha Antibody [HIF1A-84]
产品货号：PSI-33-139-100ug
产品规格：100ug
背景资料：HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (alpha and beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIFs regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.
保存建议：HIF1 alpha 抗体 [HIF1A-84]-HIF1 alpha Antibody [HIF1A-84]Aliquot and Store at 2-8℃
应用类型：Flow, IF
点击：HIF1 alpha 抗体 [HIF1A-84]-HIF1 alpha Antibody [HIF1A-84]查看更详细产品说明，更多应用、储存、价格、货期等信息请垂询艾美捷科技有限公司。更多ProSci公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。
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