P16 抗体 [2D9A12] -P16 Antibody

P16 抗体 [2D9A12] ，P16 Antibody [2D9A12] ，P16 抗体 [2D9A12] ,P16 Antibody [2D9A12]

产品名称：P16 抗体 [2D9A12] -P16 Antibody [2D9A12]

产品货号：PSI-32-202-0.1mL

产品规格：0.1mL

背景资料：The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. The cyclins function as differentially expressed positive regulators of Cdks. Negative regulators of the cycle include the p53-inducible 21 kDa WAF1/Cip1 protein designated p21, Kip1 p27 and p16. The complexes formed by Cdk4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase. It has recently been shown that p16 binds to Cdk4 and inhibits the catalytic activity of the Cdk4/cyclin D complex. Moreover, the gene encoding p16 exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.

保存建议：P16 抗体 [2D9A12] -P16 Antibody [2D9A12] stored at -20℃, stable for one year

应用类型：E, WB, IHC

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