IKBKE 抗体 [6B4B5] -IKBKE Antibo

IKBKE 抗体 [6B4B5] ，IKBKE Antibody [6B4B5] ，IKBKE 抗体 [6B4B5] ,IKBKE Antibody [6B4B5]

产品名称：IKBKE 抗体 [6B4B5] -IKBKE Antibody [6B4B5]

产品货号：PSI-32-177-0.1mL

产品规格：0.1mL

背景资料：Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degra-dation of IκB. IκB kinase α(IKKα), previously designated CHUK, interacts with IκB-αand specifically phosphorylates IκB-αon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKα, IKKβand IKKγ(also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKαand IKKβ. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFα, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of IκBαon Ser32 and Ser36, and in NFκB activation, suggesting that IKK-i may act as an IκB kinase in the immune system.

保存建议：IKBKE 抗体 [6B4B5] -IKBKE Antibody [6B4B5] stored at -20℃, stable for one year

应用类型：E, WB

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