IGF1R 抗体 [3C8B1] -IGF1R Antibo

IGF1R 抗体 [3C8B1] ，IGF1R Antibody [3C8B1] ，IGF1R 抗体 [3C8B1] ,IGF1R Antibody [3C8B1]

产品名称：IGF1R 抗体 [3C8B1] -IGF1R Antibody [3C8B1]

产品货号：PSI-32-174-0.1mL

产品规格：0.1mL

背景资料：IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

保存建议：IGF1R 抗体 [3C8B1] -IGF1R Antibody [3C8B1] stored at -20℃, stable for one year

应用类型：E, WB, IHC

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