ADAM17 抗体-ADAM17 Antibody

ADAM17 抗体，ADAM17 Antibody，ADAM17 抗体,ADAM17 Antibody

产品名称：ADAM17 抗体-ADAM17 Antibody

产品货号：PSI-22-001-50uL

产品规格：50uL

背景资料：This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.

保存建议：ADAM17 抗体-ADAM17 AntibodyStore at -20℃

应用类型：WB,IHC,IF

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