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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human p38 MAPK (NP_620581.1).
- 保存条件:
Store at -20℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
WB
- 抗体英文名:
p38 MAPK Antibody
- 抗体名:
p38 MAPK Antibody
- 规格:
50uL
p38 MAPK 抗体,p38 MAPK Antibody,p38 MAPK 抗体,p38 MAPK Antibody
产品名称:p38 MAPK 抗体-p38 MAPK Antibody
产品货号:PSI-13-989-50uL
产品规格:50uL
背景资料:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
保存建议:p38 MAPK 抗体-p38 MAPK AntibodyStore at -20℃
应用类型:WB
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文献和实验【求助】请问如何检测RAS、MAPK、p38、p21 ?参与者:liqunfeng请问如何检测RAS、MAPK、p38、p21??谁帮帮我啊参与者:xiaolx你在网上搜搜别人的实验中怎么检测的,不就知道了。p38,我师姐做过免疫组化。参与者:zhangyuelin1999检测信号通路现在用的比较多的方法应该是Western blot,它是测细胞中的蛋白含量(半定量)的最好方法了,免疫组化检测是定性的!如果时间充裕的话,你可以两种方法都可以做的。RAS:Ras蛋白是细胞内的一种小分子GTP结合
yy59410 在下在做MAPK通路对皮肤成纤维细胞凋亡诱导的作用,我分别用p38,JNK,ERK相应的通路抑制剂阻断相应的通路后看给药后细胞的情况,发现这些通路的阻断并不能阻断药物对细胞的凋亡诱导,想请教坛子里的高手们这是怎么回事?我接下来需要做什么? 希望大侠们赐教。不甚感激啊。 chuckdouble yy59410 wrote: 在下在做MAPK通路对皮肤成纤维
相关专题 MAPK信号通路专题 p38 MAPK是1993年由Brewster等人在研究高渗环境对真菌的影响时发现的。以后又发现它也存在于哺乳动物 的细胞内,也是MAPKs的亚类之一,其性质与JNK相似,同属应激激活的蛋白激酶。目前已发现p38MAPK有5个异构体,分别为p38α(p38)、p38β1、p38β2、p38γ、p38δ。其分布具有组织特异性:p38α、p38β1、p38β2在各种组织细胞中广泛存在,p38γ仅在骨骼肌细胞中存在
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