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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human ERBB4 (NP_005226.1).
- 保存条件:
Store at -20℃
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
兔
- 应用范围:
WB
- 抗体英文名:
ERBB4 Antibody
- 抗体名:
ERBB4 Antibody
- 规格:
50uL
ERBB4 抗体,ERBB4 Antibody,ERBB4 抗体,ERBB4 Antibody
产品名称:ERBB4 抗体-ERBB4 Antibody
产品货号:PSI-13-273-50uL
产品规格:50uL
背景资料:This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
保存建议:ERBB4 抗体-ERBB4 AntibodyStore at -20℃
应用类型:WB
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文献和实验Modeling Schizophrenia in Neuregulin 1 and ErbB4 Mutant Mice
. However, genetic studies have recently identified many susceptibility genes of this disorder including neuregulin 1 (NRG1 ) and its receptor ErbB4 . Arguably, relevant mutant mice have provided a unique opportunity to model “schizophrenia” in animals
ERBB4 Mutation Analysis: Emerging Molecular Target for Melanoma Treatment
is the ERBB4 receptor, or HER4, a member of the Erb receptor family, which has recently been shown to be a major oncogenic “driver” in melanoma. Mutated ERBB4 signaling activates both aberrant ERBB4 and PI3K-AKT signal transduction, mediates sensitivity
在免疫反应方面,基于抗原的刺激在体内形成、并与抗原作特异性结合的蛋白质之总称。其化学实质是免疫球蛋白。抗体,按照抗原抗体反应的类型可分别称为沉淀素、凝集素、溶血素、溶菌素、抗毒素、中和抗体等,但这些并不等于有相应的不同抗体存在,一般多只表明抗体反应的多样性而已。抗体在血清中含量最多(体液抗体=humoral antibody);含有某特定抗体的血清称为抗血或免疫血清。
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