DIRAS3 抗体-DIRAS3 Antibody

DIRAS3 抗体，DIRAS3 Antibody，DIRAS3 抗体,DIRAS3 Antibody

产品名称：DIRAS3 抗体-DIRAS3 Antibody

产品货号：PSI-8139-0.02mg

产品规格：0.02mg

背景资料：DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).

保存建议：DIRAS3 抗体-DIRAS3 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB

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