Dinutuximab (ganglioside GD2)

Dinutuximab (ganglioside GD2) 抗体, 单克隆，Dinutuximab (ganglioside GD2) Antibody, Monoclonal，Dinutuximab (ganglioside GD2) 抗体, 单克隆,Dinutuximab (ganglioside GD2) Antibody, Monoclonal

产品名称：Dinutuximab (ganglioside GD2) 抗体, 单克隆-Dinutuximab (ganglioside GD2) Antibody, Monoclonal

产品货号：PSI-10-595-0.1mg

产品规格：0.1mg

背景资料：Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14.18 and the constant regions of human IgG1 heavy-chain and kappa light-chain. By binding to GD2, dinutiximab induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity of tumor cells thereby leading to apoptosis and inhibiting proliferation of the tumour. It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. Despite a high clinical response seen after first-line treatment, the fully eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse. Current strategies for treatment include immunotherapy with drugs such as dinutuximab to target surviving neuroblastoma cells and to prevent relapse.

保存建议：Dinutuximab (ganglioside GD2) 抗体, 单克隆-Dinutuximab (ganglioside GD2) Antibody, MonoclonalStore at -80℃

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