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- ProSci
- 美国
- PSI-7707-0.02mg
- 2025年07月10日
- E, WB, IHC-P, IF
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1.<br>The immunogen is located within the last 50 amino acids of FMR1.
- 保存条件：
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期：
1年
- 级别：
科研级别
- 库存：
100
- 供应商：
艾美捷科技
- 宿主：
兔
- 应用范围：
E, WB, IHC-P, IF
- 抗体英文名：
FMR1 Antibody
- 抗体名：
FMR1 Antibody
- 规格：
0.02mg
FMR1 抗体，FMR1 Antibody，FMR1 抗体,FMR1 Antibody
产品名称：FMR1 抗体-FMR1 Antibody
产品货号：PSI-7707-0.02mg
产品规格：0.02mg
背景资料：Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).
保存建议：FMR1 抗体-FMR1 Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型：E, WB, IHC-P, IF
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文献和实验The CGG Repeat and the FMR1 Gene
This review intends to provide the different DNA methods for diagnosis of the repeat in the FMR1 gene. The two DNA methods to determine the CGG repeat size are Southern blot hybridization and the polymerase chain reaction (PCR), including
Epigenetic Modifications of the FMR1 Gene
The fragile X syndrome (FXS), the most common cause of heritable intellectual disability, is caused by expansion of a CGG repeat located at the 5′ UTR of the FMR1 gene and subsequent epigenetic modifications of its promoter. Epigenetic
Development and Characterization of Antibodies that Immunoprecipitate the FMR1 Protein
The ability to generate antibodies that recognize a given protein relies on that protein’s “antigenicity”, i.e., its ability to appear foreign to the host immune system. Thus, proteins that are highly conserved among species are often poor
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