TMEM59L antibody was raised against a 19 amino acid synthetic peptide near carboxy terminus of human TMEM59L.<br>The immunogen is located within amino acids 220 - 270 of TMEM59L.
保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
背景资料:TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.