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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Anti-B-raf antibody (<strong>5777</strong>) was raised against a peptide corresponding to 18 amino acids near the center of human B-raf. <br> The immunogen is located within amino acids 330 - 380 of B-raf.
- 保存条件:
stored at 4℃ for three months and -20℃, stable for up to one year
- 保质期:
1年
- 级别:
科研级别
- 库存:
100
- 供应商:
艾美捷科技
- 宿主:
鸡
- 应用范围:
E, WB
- 抗体英文名:
B-raf Antibody
- 抗体名:
B-raf Antibody
- 规格:
0.02mg
B-raf 抗体,B-raf Antibody,B-raf 抗体,B-raf Antibody
产品名称:B-raf 抗体-B-raf Antibody
产品货号:PSI-5777-0.02mg
产品规格:0.02mg
背景资料:B-raf Antibody: B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. The Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways interact with each other to regulate growth and in some cases tumorigenesis. Mutations in B-raf have been associated with several cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung, leading to speculation on the possibility of B-raf as a therapeutic target for treating cancers. Mutations in this gene have also been associated with cardiofaciocutaneous syndrome (CFCS), a disease characterized by heart defects, mental retardation and a distinctive facial appearance.
保存建议:B-raf 抗体-B-raf Antibody stored at 4℃ for three months and -20℃, stable for up to one year
应用类型:E, WB
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文献和实验Monitoring Oncogenic B-RAF-Induced Senescence in Melanocytes
The B-RAF kinase is a downstream effector of the RAS family of proto-oncogenes and is constitutively activated in the majority of human melanomas. The common oncogenic B-RAFV600E mutant cooperates with additional genetic lesions to transform
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