RUSC1 抗体-RUSC1 Antibody

RUSC1 抗体，RUSC1 Antibody，RUSC1 抗体,RUSC1 Antibody

产品名称：RUSC1 抗体-RUSC1 Antibody

产品货号：PSI-5411-0.02mg

产品规格：0.02mg

背景资料：RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IκB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-κB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-κB activation pathway.

保存建议：RUSC1 抗体-RUSC1 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, WB

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